- Matchday 28
FK Smorgon10
Dinamo Brest1113:00Ended- Matchday 28
Slaviya Mozyr10
Grodno1115:00Ended- Matchday 29
D. Minsk22Grodno0011:00Ended- Matchday 29
- Dinamo Brest00
Shakhter3211:00Ended - Matchday 29
SKA-193820Slaviya Mozyr3111:00Ended- Matchday 29
FK Minsk11
FK Isloch Minsk0011:00Ended- Matchday 29
FK Slutsk31
Rukh Brest0011:00Ended- Matchday 29
FK Gomel00FK Smorgon0011:00Ended- Matchday 29
Torpedo Zhodino00
Borisov3011:00Ended- Matchday 29
FK Vitebsk3
Sputnik Rechytsa0dec.Ended- Matchday 30
- Borisov40FK Vitebsk0011:00Ended
- Matchday 30
- FK Isloch Minsk00SKA-19384211:00Ended
- Matchday 30
- Grodno32Torpedo Zhodino1011:00Ended
- Matchday 30
- Rukh Brest31Dinamo Brest2111:00Ended
- Matchday 30
- Shakhter00FK Gomel1111:00Ended
- Matchday 30
- Slaviya Mozyr00D. Minsk0011:00Ended
- Matchday 30
- FK Smorgon11FK Minsk0011:00Ended
- Matchday 30
- Sputnik Rechytsa0FK Slutsk3dec.Ended
Standing
| # | Team | Team | M | W | D | L | Score | Diff | Pts | |
|---|---|---|---|---|---|---|---|---|---|---|
| 1 | | Shakhter Soligorsk | Shakhter | 30 | 24 | 3 | 3 | 62:18 | 44 | 75 |
| 2 | | BATE Borisov | Borisov | 30 | 19 | 8 | 3 | 61:27 | 34 | 65 |
| 3 | | Dinamo Minsk | D. Minsk | 30 | 19 | 5 | 6 | 55:20 | 35 | 62 |
| 4 | | FK Gomel | FK Gomel | 30 | 17 | 8 | 5 | 57:23 | 34 | 59 |
| 5 | | Rukh Brest | Rukh Brest | 30 | 16 | 10 | 4 | 52:28 | 24 | 58 |
| 6 | | Dinamo Brest | Dinamo Brest | 30 | 8 | 14 | 8 | 32:32 | 0 | 38 |
| 7 | | FK Vitebsk | FK Vitebsk | 30 | 9 | 10 | 11 | 37:41 | -4 | 37 |
| 8 | | Torpedo-BelAZ Zhodino | Torpedo Zhodino | 30 | 10 | 6 | 14 | 38:43 | -5 | 36 |
| 9 | | FK Slutsk | FK Slutsk | 30 | 9 | 8 | 13 | 36:44 | -8 | 35 |
| 10 | | FK Isloch Minsk | FK Isloch Minsk | 30 | 9 | 7 | 14 | 38:47 | -9 | 34 |
| 11 | | Neman Grodno | Grodno | 30 | 9 | 7 | 14 | 36:36 | 0 | 34 |
| 12 | | FK Minsk | FK Minsk | 30 | 8 | 9 | 13 | 32:52 | -20 | 33 |
| 13 | | SKA-1938 Minsk | SKA-1938 | 30 | 8 | 9 | 13 | 35:42 | -7 | 33 |
| 14 | | FK Slaviya Mozyr | Slaviya Mozyr | 30 | 8 | 8 | 14 | 42:50 | -8 | 32 |
| 15 | | FK Smorgon | FK Smorgon | 30 | 4 | 9 | 17 | 26:66 | -40 | 21 |
| 16 | | Sputnik Rechytsa | Sputnik Rechytsa | 30 | 2 | 1 | 27 | 12:82 | -70 | 7 |
- Champions League Quali.
- Europa Conference League qualifying
- Relegation play-offs
- Relegation
- Am 14. Juli 2021 zog Sputnik Rechytsa seine Mannschaft aus dem Wettbewerb zurück. Die verbleibenden Saisonspiele wurden jeweils mit 0:3 gewertet.
Matchday 30
28.11.2021
Topscorer
| # | Player | Team | Matches | Scores | 11m | Ratio | |||
|---|---|---|---|---|---|---|---|---|---|
| 1 |  | | D. Darboe | Dembo Darboe | Shakhter Soligorsk | 29 | 19 | 2 | 0,66 |
| 2 |  | | A. Solovey | Andrey Solovey | FK Gomel | 29 | 18 | 1 | 0,62 |
| 3 |  | | M. Skavysh | Maksim Skavysh | BATE Borisov | 29 | 13 | 1 | 0,45 |
 | | S. Bilenkyi | Stanislav Bilenkyi | Dinamo Brest | 27 | 13 | 1 | 0,48 | |
| 5 |  | | A. Mbengue | Ablaye Mbengue | Dinamo Minsk | 15 | 10 | 1 | 0,67 |
Goals
| Team | Matches | Goals/M | Goals | ||
|---|---|---|---|---|---|
| 1 | | Shakhter Soligorsk | 29 | 2,03 | 59 |
| 2 | | BATE Borisov | 29 | 2,00 | 58 |
| 3 | | FK Gomel | 29 | 1,86 | 54 |
Goals against
| Team | Matches | Goals conceded | |||
|---|---|---|---|---|---|
| 1 | | FK Smorgon | 29 | 2,28 | 66 |
| 2 | | FK Minsk | 29 | 1,79 | 52 |
| 3 | | FK Slaviya Mozyr | 29 | 1,72 | 50 |
